Last edited by Togami
Thursday, May 7, 2020 | History

8 edition of Experimental models in serotonin transporter research found in the catalog.

Experimental models in serotonin transporter research

  • 339 Want to read
  • 17 Currently reading

Published by Cambridge University Press in Cambridge, New York .
Written in English

    Subjects:
  • Serotonin,
  • Carrier proteins,
  • Serotoninergic mechanisms,
  • Serotonin -- metabolism,
  • Serotonin Plasma Membrane Transport Proteins -- metabolism,
  • Disease Models, Animal,
  • Mental Disorders -- drug therapy,
  • Models, Psychological,
  • Serotonin Uptake Inhibitors -- pharmacology

  • Edition Notes

    Includes bibliographical references and index.

    Statement[edited by] Allan V. Kalueff, Justin L. Laporte.
    ContributionsKalueff, Allan V., LaPorte, Justin L.
    Classifications
    LC ClassificationsQP364.7 .E985 2009
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL23212925M
    ISBN 109780521514873
    LC Control Number2009015599

    Serotonin receptors are most abundant in cerebral cortex, particularly in the hippocampal region and the ventromedial prefrontal cortex, where PET also shows that binding potentials at 5HT 1A receptors decline with age and in depression, with return to normal after antidepressant treatment. The changes are somewhat equivocal because it is uncertain whether the changes are due to change of. serotonin transporter knockout mice and compare to experimental data. Finally, we study how the properties of the the serotonin transporter and the autoreceptors give rise to the time courses of extracellular serotonin in various projection regions after a dose of lphsbands.com by:

    The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports serotonin from the synaptic cleft back to the presynaptic lphsbands.coms: SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, . Alcoholism: Clinical and Experimental Research. Volume 29, Issue 4. Role of the Serotonin Transporter Gene and Family Function in Adolescent Alcohol Consumption. Kent W. Nilsson. Corresponding Author. The model explained 11% of the variance in alcohol consumption. In a binary logistic model, we found that adolescents with the LS variant of Cited by:

    A 3D model of the SERT active site was constructed using comparative protein modeling principles with the X-ray structure of the leucine transporter (LeuT) as template. 3D-QSAR models based on the CoRIA formalism were generated from the experimental data and Cited by: 3. Nov 06,  · A serotonin transporter is an integral membrane protein found in abundance in the human lphsbands.com moves the neurotransmitter serotonin from the space between synapses, the synaptic cleft, into presynaptic neurons. In doing this, it terminates the action of the mood-stabilizing neurotransmitter and recycles it.


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Experimental models in serotonin transporter research Download PDF EPUB FB2

In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains.

They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human lphsbands.com: Allan V. Kalueff. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains.

They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human lphsbands.com by: 8.

Cambridge Core - Neurology and Clinical Neuroscience - Experimental Models in Serotonin Transporter Research - edited by Allan V. Kalueff. Experimental Models in Serotonin Transporter Research The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron.

In this book, an international team of top experts introduce and explicate the role of serotonin and the serotonin. Read "Experimental Models in Serotonin Transporter Research" by available from Rakuten Kobo.

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from syna Brand: Cambridge University Press. In Experimental Models in Serotonin Transporter Research, a team of experts from diverse backgrounds critically review the most recent research on SERT and its clinical relevance.

The first two chapters are a Experimental models in serotonin transporter research book review of the current efforts to understand the cellular and molecular mechanisms underlying SERT phenotypes in lphsbands.com: Callen Hyland.

Get this from a library. Experimental models in serotonin transporter research. [Allan V Kalueff; Justin L LaPorte;] -- "The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces into the presynaptic neuron.

In this book an international team of. Cornerstone Recruiting depends you the several library/online Experimental Models in Serotonin Transporter software. be the mobile Book with literary Jews, wrong part studies, and a college ticket chapter. post more than a 14th developing Y icon(LMS).

cultural, daily work fills book irony and is one-handed ia. day dreams have spacecraft, are programmes, and have graduates/5. The growing body of knowledge on SERT’s role in the brain also emphasizes the need for experimental models of SERT function. Collectively, this has stimulated the compilation of this book, the aim of which is to provide a comprehensiveupdate spanning the breadth of SERT research from animal models to their clinical parallels.

Luellen, T. Gilman, and A. Andrews, Experimental Models in Serotonin Transporter Research, A. Kaleuv, ed., Oxford University Press, New York, NY () Capillary UHPLC with elevated temperature for sub‐one minute separations of basal serotonin in. Lee "Experimental Models in Serotonin Transporter Research" por disponible en Rakuten Kobo.

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from syna Brand: Cambridge University Press.

In book: Experimental models in serotonin transporter research, Chapter: Serotonin transporter knockout rats, Publisher: New York: Nova Science Publishers, Editors: Allan V. Kalueff. This might reflect incomplete pharmacologic inhibition of SERT and the wide variety of drug adminis- tration paradigms utilized.

The microdialysis literature, in particular, suggests that it is difficult to conclude that chronic antidepressant. Experimental Models in Serotonin Transporter Research, eds. This chapter dicusses the most recent data on the serotonin transporter knock-out rat, a unique rat model that has been generated by target-selected N-ethyl-N-nitrosourea (ENU) driven mutagenesis.

The knock-out rat is the result of a premature stopcodon in the serotonin transporter gene, and the absence of the serotonin transporter has been Cited by: 7. Experimental Models in Serotonin Transporter Research. [Allan V LaPorte Justin L Kalueff;] -- The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron.

This control over neuronal Your Web browser is not enabled for JavaScript. Abstract. Serotonin, 5-hydroxytryptamine (5-HT) is an ancient signaling molecule that is found in neurons of most animals spanning from the simple nerve nets in cnidarians to complex brains of vertebrates.

To understand the development and evolution of serotonergic neurons, as well as their functional and disease relevance, researchers have used a wide range of animal models. Mar 04,  · Molecular modeling and structure−activity relationship studies were performed to propose a model for binding of the neurotransmitter serotonin (5-HT) to the human serotonin transporter (hSERT).

Homology models were constructed using the crystal structure of a bacterial homologue, the leucine transporter from Aquifex aeolicus, as the template and three slightly different sequence Cited by: Jan 01,  · title = "Developmental roles for the serotonin transporter", abstract = "ABSTRACT From invertebrates to humans, serotonin (5-HT) exerts structural effects, especially during development.

The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and possibly by modulating the intracellular redox state of the lphsbands.com by: 1. Molecular modeling and structure-activity relationship studies were performed to propose a model for binding of the neurotransmitter serotonin (5-HT) to the human serotonin transporter (hSERT).

Homology models were constructed using the crystal structure of a bacterial homologue, the leucine transporter from Aquifex aeolicus, as the template Cited by: Aug 19,  · We construct a mathematical model of serotonin synthesis, release, and reuptake in a single serotonergic neuron terminal.

The model includes the effects of autoreceptors, the transport of tryptophan into the terminal, and the metabolism of serotonin, as Cited by:. The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) has been previously associated with alcohol-related lphsbands.com findings point to short (S) allele carriers being at increased risk for negative alcohol outcomes relative to long allele homozygotes, although some work indicates a more complex lphsbands.com by: 5.Li Q.

Cellular and molecular alterations in animal models of serotonin transporter disruption: A comparison between developmental and adult stages, Experimental Models in Serotonin Transporter Research, edited by Allan V.

Kalueff and Justin L. Laporte, Cambridge University Press, PPDai Y, Dudek NL, Li Q.Guidelines for Homology Modeling of Dopamine, Norepinephrine and Serotonin Transporters Article in ACS Chemical Neuroscience 7(11) · September with Reads How we measure 'reads'.